Genes and DNA by Charlotte K. Omoto; Paul F. LurquinCovering newsworthy aspects of contemporary biology -- gene therapy, the Human Genome Project, DNA testing, and genetic engineering -- as well as fundamental concepts, this book, written specifically for nonbiologists, discusses classical and molecular genetics, quantitative and population genetics -- including cloning and genetic diseases -- and the many applications of genetics to the world around us, from genetically modified foods to genetic testing. With minimal technical terminology and jargon, Genes and DNA facilitates conceptual understanding. Eschewing the organization of traditional genetics texts, the authors have provided an organic progression of information: topics are introduced as needed, within a broader framework that makes them meaningful for nonbiologists. The book encourages the reader to think independently, always stressing scientific background and current facts.
Genetics by Karvita B. AhluwaliaAbout the Book: Endeavours to make this seemingly difficult subject understandable and enjoyable for the readers. It provides an account of classical and modern genetics with new developments in the field. The scope of each chapter has been broadened enough to provide information on historical landmarks as well as of new facts from current issues of major journals. Chapters on gene transcription, regulation, human genetics, recombinant DNA and genomics have been given special attention to create awareness about future areas in this growing field. Experimental work is supported by methodologies and illustrations. The text is useful for students pursuing courses in cell and molecular biology, biophysics, anthropology and agricultural sciences at universities, medical colleges and similar institutions. Contents: The Pre-Mendelian Era and Mendelism Interaction of Genes Environment and Gene Expression Quantitative or Polygenic Inheritance Multiple Alleles Cell Division and Chromosome Theory of Inheritance Chi-Square Test and Probability Linkage, Recombination and Gene Mapping Extranuclear Transmission of Traits The Genetic Control of Sex Variations in Chromosome Number Variations in Chromosome Structure Nature of the Genetic Material The Structure and Replication of DNA Gene Transcription and Translation into Proteins Genetic Regulation in Prokaryotes and Eukaryotes Genetics of Bacteria Genetics of Viruses The Eukaryotic Chromosome Mutations Human Genetics Fine Structure of the Gene Recombinant DNA Technology Applications of Recombinant DNA Technology Genomics Populations and Gene Frequencies Origin of Life-Evolution of Man
Evolutionary Conservation Genetics by Jacob Ho¨glundConservation genetics focuses on understanding the role of genetic variation for population persistence. This book is about the methods used to study genetic variation in endangered species and whether genetic variation matters in the extinction of species. -;Conservation genetics focuses on understanding the role and requirement of genetic variation for population persistence. However, considerable debate now surrounds the role of genetic factors (as opposed to non-genetic factors such as habitat destruction etc.) in population extinction, and a comprehensive synthesis is now timely. Can extinction be explained by habitat destruction alone or is lack of genetic variation a part of the explanation? The book thoroughly reviews the. arguments for a role of genetics in the present biodiversity crisis. It describes the methods used to study genetic variation in endangered species and examines the influence of genetic variation in the extinction of species. To date, conservation genetics has predominantly utilized neutral genetic markers e.g. microsatellites. However, with the recent advances in molecular genetics and genomics it will soon be possible to study 'direct gene action', following the fate of genetic variation at the level of DNA, through expression, to proteins in order to determine how such phenotypes fare in populations of free living organisms. Evolutionary Conservation Genetics explores these exciting avenues of future. research potential, integrating ecological quantitative genetics with the new genome science. It is now more important than ever that we ask relevant questions about the evolutionary fate of endangered populations throughout the globe and incorporate our knowledge of evolutionary processes and the distribution. of genetic diversity into effective conservation planning and action. -
Publication Date: 2009-01-01
An Introduction to Human Molecular Genetics by Jack J. PasternakAn Introduction to Human Molecular Genetics Second Edition Jack J. Pasternak The Second Edition of this internationally acclaimed text expands its coverage of the molecular genetics of inherited human diseases with the latest research findings and discoveries. Using a unique, systems-based approach, the text offers readers a thorough explanation of the gene discovery process and how defective genes are linked to inherited disease states in major organ and tissue systems. All the latest developments in functional genomics, proteomics, and microarray technology have been thoroughly incorporated into the text. The first part of the text introduces readers to the fundamentals of cytogenetics and Mendelian genetics. Next, techniques and strategies for gene manipulation, mapping, and isolation are examined. Readers will particularly appreciate the text's exceptionally thorough and clear explanation of genetic mapping. The final part features unique coverage of the molecular genetics of distinct biological systems, covering muscle, neurological, eye, cancer, and mitochondrial disorders. Throughout the text, helpful figures and diagrams illustrate and clarify complex material. Readers familiar with the first edition will recognize the text's same lucid and engaging style, and will find a wealth of new and expanded material that brings them fully up to date with a current understanding of the field, including: * New chapters on complex genetic disorders, genomic imprinting, and human population genetics * Expanded and fully revised section on clinical genetics, covering diagnostic testing, molecular screening, and various treatments This text is targeted at upper-level undergraduate students, graduate students, and medical students. It is also an excellent reference for researchers and physicians who need a clinically relevant reference for the molecular genetics of inherited human diseases.
Publication Date: 2005-06-14
Reproductive Genetics by Sean KehoeGreat progress has been made in the field of genetics within the past decade. This, combined with our growing knowledge, has impacted on this important area with interesting consequences. The ability to identify genetic defects before implantation, to diagnose fetal abnormalities and to introduce screening programmes means that genetic testing now has a major role in preventive medicine. These topics are discussed in detail in the book. In parallel with these advances, other aspects that cannot be ignored, such as education of the public and the potential ethical dilemmas that may arise by virtue of these new methodologies, are raised and discussed in this volume, which is based on the 57th RCOG Study Group and includes a set of consensus views from the expert participants.
Publication Date: 2009-01-01
Introduction to Genomics by Arthur LeskOur genome is the blueprint to our existence: it encodes all the information we need to develop from a single cell into a hugely complicated functional organism. But it is more than a static information store: our genome is a dynamic, tightly-regulated collection of genes, which switch on and off in many combinations to give the variety of cells from which our bodies are formed. But how do we identify the genes that make up our genome? How do we determine their function? And how dodifferent genes form the regulatory networks that direct the processes of life?Introduction to Genomics is a fascinating insight into what can be revealed from the study of genomes: how organisms differ or match; how different organisms evolved; how the genome is constructed and how it operates; and what our understanding of genomics means in terms of our future health and wellbeing. Covering the latest techniques that enable us to study the genome in ever-increasing detail, the book explores what the genome tells us about life at the level of the molecule, the cell, and the organism. Learning features throughout make this book the ideal teaching and learning tool: extensive end of chapter exercises and problems help the student to fully grasp the concepts being presented, while end of chapter weblems (web-based problems) and lab assignments give the student the opportunityto engage with the subject in a hands-on manner. The field of genomics is enabling us to analyze life in more detail than ever before; Introduction to Genomics is the perfect guide to this enthralling subject.Online Resource CentreThe Online Resource Centre to accompany Introduction to Genomics featuresFor lecturers: Figures from the book in electronic formatFor students: Answers to end-of-chapter exercisesGuided tour of web sites in genomicsHints to end-of-chapter problemsRotating figur