Theoretical approach: Limit your topic to a particular approach to the issue. For example, if your topic concerns cloning, examine the theories surrounding of the high rate of failures in animal cloning.
Aspect or sub-area: Consider only one piece of the subject. For example, if your topic is human cloning, investigate government regulation of cloning.
Time: Limit the time span you examine. For example, on a topic in genetics, contrast public attitudes in the 1950's versus the 1990's.
Population group: Limit by age, sex, race, occupation, species or ethnic group. For example, on a topic in genetics, examine specific traits as they affect women over 40 years of age.
Geographical location: A geographic analysis can provide a useful means to examine an issue. For example, if your topic concerns cloning, investigate cloning practices in Europe or the Middle East.